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Captopril Manufacturing Thailand, the United Kingdom and USA
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Captopril

  • Product Name : Captopril
  • Grade : IP / BP / USP
  • Therapeutic Category : Antihypertensive
  • CAS No : 62571-86-2
  • COA : Available
  • MSDS : Available

Description

Captopril (rINN) is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first ACE inhibitor developed and was considered a breakthrough both because of its novel mechanism of action and also because of the revolutionary development process.

 

 Specification:

 

Product name

Captopril

Appearance

White or almost white crystalline powder

Solubility

Freely soluble in water,in methylene chloride and in methanol.

It dissolves in dilute solutions of alkali hydroxides.

Identification

Ir spectrum conformod tothat of captopril crs

Appearance of solutions

Clear and colorless

Melting range

Between 104°c and 110°c

Specific optical rotation

-125° to -130°

Related substance

Ampa

Captopril disulfide

Single unknown impurity

Tctal unknown impurities

 

Not more than 0.2%

Not more than 1.0%

Not more than 0.2%

Not more than 0.5%

Heavy metals

Not more than 0.003%

Loss on drying

Not more than 1.0%

Sulphated ash

Not more than 0.2%

Assay

97.5%~102.0% calculated on anhydrous basis

                                                                                                                                                                             

Packaging details:

 

Packaging details:

25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

Storage:

Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat

Shelf Life:

5 years if sealed and store away from direct sun light.

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